David Trimble, the former Ulster Unionist leader, was speaking on the Daily Politics Show about the upcoming Scottish Referendum.
"If the referendum in Scotland goes in the way I regard as the wrong result, that will change the political context in Northern Ireland," he said.
Trimble added that "would cause strains".
"It would put what is now a non-issue [a possible referendum] into a major issue and it would be divisive, obviously."
On Thursday, 18 September, registered voters in Scotland will be asked the referendum question: "Should Scotland be an independent country?"
Those voters will have a straight choice between "yes" and "no".